Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Home Print this page Email this page Small font size Default font size Increase font size Users Online: 265
ORIGINAL ARTICLE
Year : 2022  |  Volume : 23  |  Issue : 2  |  Page : 105-110

Acanthosis Nigricans: An overt clinical marker of insulin resistance and its association with serum adiponectin levels in obese pediatric population


1 Department of Dermatology, Government Medical College, Patiala, Punjab, India
2 Department of Dermatology, Civil Hospital, Kapurthala, Punjab, India
3 Department of Paediatrics, Government Medical College, Patiala, Punjab, India
4 Department of Biochemistry, Government Medical College, Patiala, Punjab, India

Correspondence Address:
Dr. Dimple Chopra
No. 27, Bank Colony, Patiala - 147 001, Punjab
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijpd.ijpd_102_21

Rights and Permissions

Background: Childhood obesity (OB) is becoming increasingly prevalent in recent times. Acanthosis nigricans (AN) is a clinical condition linked to OB and insulin resistance (IR). Serum adiponectin is one of the major adipokines that is inversely related to the severity of IR. Objective: The main aim of this study is to evaluate the correlation of severity (grades) of AN with serum adiponectin levels and IR. Materials and Methods: A total of 80 subjects were studied, 50 having OB with AN (OB+AN) and 30 having OB without AN (OB-AN), having age 10–18 years fulfilling the set inclusion and exclusion criteria. Body mass index, fasting blood glucose, HOMA-IR (Homeostatic Model Assessment of IR) and serum adiponectin levels were measured in all subjects. Results: Compared to OB-AN group, OB+AN group had statistically significant lower serum adiponectin levels and higher HOMA-IR values. AN grades correlated positively with HOMA-IR values and negatively with serum adiponectin levels in a statistically significant manner. Conclusion: Grading AN clinically can be easy and useful tool to detect IR in obese subjects. Serum adiponectin levels can be used as another lab parameter in obese subjects guiding the severity of AN.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed885    
    Printed22    
    Emailed0    
    PDF Downloaded87    
    Comments [Add]    

Recommend this journal