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CASE REPORT
Year : 2022  |  Volume : 23  |  Issue : 2  |  Page : 170-171

Early-onset, severe prurigo nodularis in a young child with atopic dermatitis treated successfully with dupilumab


Department of Paediatrics, Paediatric Dermatology Unit, Women and Children Hospital Kuala Lumpur, Kuala Lumpur, Malaysia

Correspondence Address:
Dr. Henrietta Albela
Department of Paediatrics, Paediatric Dermatology Unit, Women and Children Hospital Kuala Lumpur, Jalan Pahang, 50586, Kuala Lumpur
Malaysia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijpd.ijpd_175_21

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Prurigo nodularis is an extremely pruritic skin condition as a result of chronic and vicious cycle of itching and scratching. It is rare in children. We report a case of a 4-year-old child with a background of poorly controlled atopic dermatitis with early-onset, severe prurigo nodularis, who was treated successfully with off-label use of dupilumab injection. There was a significant reduction in itchiness by week 2 of treatment, and achieved 80% reduction in Eczema Area and Severity Index with almost complete resolution of prurigo nodules by week 8. Dupilumab can be considered a treatment option for young pediatric patients with early-onset prurigo nodularis.


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